Association of adipokines with insulin resistance and metabolic syndrome including obesity and diabetes

Adipose tissue (AT) acts as a highly active endocrine organ, which secretes wide range of adipokine hormones. In the past few years, several adipokines (leptin, adiponectin, resistin etc.) have been discovered showing metabolic consequences in relation to insulin resistance (IR), obesity and diabetes. These are considered be an important component playing role regulation energy metabolism. They shown involved pathogenesis syndrome (MetS) cardiac diseases. The current article provides holistic summary recent knowledge on emphasizes their importance association with IR, obesity, diabetes MetS. Adipokines such leptin, tumor necrosis factor-alpha (TNF-α) array functions disease associated it, e.g. appetite balance body, suppression atherosclerosis liver fibrosis, type 2 (T2D) IR. An adipokine, Interleukin-6 (IL-6), also correlates positively human IR elevated level IL-6 predicts development T2D. All these hormones correlation homeostasis, glucose lipid metabolism, cardiovascular function immunity. possible connections extended biological emphasis AT secreted investigator MetS, now no longer only storage site.